Carolina Borrelli
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Hi, I’m Carolina and I am part of the Centre for Doctoral Training in the Advanced Characterisation of Materials (CDT-ACM). I am based at UCL with Bart Hoogenboom and Imperial with Andrew Edwards.
My project is focussed on understanding how polymyxin antibiotics can kill Gram-negative bacteria. More specifically how they disrupt both inner and outer membranes to then lead to cell lysis. This is essential as we must understand how the current antibiotics work in order to develop new and more effective ones. I use Atomic Force Microscopy to characterise the outer membrane of Escherichia coli upon injection of polymyxins and fluorescence studies to look at membrane permeation. In my free time I like to run and hike to explore new places!
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