Bart Hoogenboom
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Bart Hoogenboom is a Professor of Biophysics at the Department of Physics and Astronomy (UCL) and the London Centre for Nanotechnology, where he is also lead scientist for its atomic force microscopy facilities. He was initially trained as a solid-state physicist, working on correlated-electron systems and scanning probe microscopy. After his PhD, he pioneered atomic-resolution AFM in solution and next gradually shifted his focus to nanoscale biological structures and processes. At UCL, this has led to the first visualisation of the DNA double helix and structural variations thereof in solution; the development of novel nanomechanical and computational approaches to understand the physics of transport selectivity into and out of the cell nucleus via nuclear pore complexes; the understanding of membrane disruption by various natural and engineered antimicrobial peptides and by pore forming proteins employed both by bacteria and by the vertebrate immune system, which has in part involved high-resolution AFM imaging of live bacteria.
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