Alice carried out her EngD at UCL in the Hoogenboom Lab developing techniques for high resolution imaging of biomolecules in solution. During her EngD, she collaborated with both the National Physical Laboratory, and Bruker (CA, USA).
Following her EngD, she undertook research project with Bart as part of a collaboration with Medimmune, a branch of AstraZeneca, to visualise novel single molecule targeted drug interactions as part of their drug discovery pipeline. This project was subsequently extended as a PhD for Alex Yon.
Following this, Alice was awarded an EPSRC Doctoral Prize fellowship to investigate how DNA structure varies at the single-molecule level, and how this can influence DNA-DNA and DNA-protein interactions. Most recently she was awarded a MRC/UKRI Innovation Fellowship to exploit her high resolution DNA imaging techniques to improve our understanding of how DNA interactions affect anti-cancer and antibacterial therapeutic targets, towards an improved drug discovery pipeline.
A. Pyne, M.-P. Pfeil, I. Bennett, J. Ravi, P. Iavicoli, B. Lamarre, A. Roethke, S. Ray, H. Jiang, A. Bella, B. Reisinger, D. Yin, B. Little, J. C. Muñoz-García, E. Cerasoli, P. J. Judge, N. Faruqui, L. Calzolai, A. Henrion, G. J. Martyna, C. R. M. Grovenor, J. Crain, B. W. Hoogenboom, A. Watts and M. G. Ryadnov, Chem. Sci., 2017, 8, 1105–1115.
L. Messager, J. R. Burns, J. Kim, D. Cecchin, J. Hindley, A. L. B. Pyne, J. Gaitzsch, G. Battaglia and S. Howorka, Angew. Chem., 2016, 128, 11272–11275.
B. Klejevskaja, A. L. B. Pyne, M. Reynolds, A. Shivalingam, R. Thorogate, B. W. Hoogenboom, L. Ying and R. Vilar, Chem. Commun., 2016, 52, 12454–12457.
A. L. B. Pyne and B. W. Hoogenboom, in Chromosome Architecture: Methods and Protocols, ed. M. C. Leake, Springer New York, New York, NY, 2016, pp. 47–60.
A. Pyne, R. Thompson, C. Leung, D. Roy and B. W. Hoogenboom, Small, 2014, 10, 3257–3261.
P. D. Rakowska, H. Jiang, S. Ray, A. Pyne, B. Lamarre, M. Carr, P. J. Judge, J. Ravi, U. I. M. Gerling, B. Koksch, G. J. Martyna, B. W. Hoogenboom, A. Watts, J. Crain, C. R. M. Grovenor and M. G. Ryadnov, Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 8918–8923.
C. Leung, A. Bestembayeva, R. Thorogate, J. Stinson, A. Pyne, C. Marcovich, J. L. Yang, U. Drechsler, M. Despont and T. Jankowski, Nano Lett, 2012, 12, 3846–3850.
A. Pyne, W. Marks, L. Picco, P. Dunton, A. Ulcinas, M. E Barbour, S. Jones, J. K. Gimzewski and M. J. Miles, Arch. Histol. Cytol., 2009, 72, 209–215.